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Post by Davef on Nov 30, 2020 17:25:20 GMT
Newcastle, Stafford and East and South Staffs are all below 300. Fingers crossed Stoke-on-Trent will follow next week.
Not that it will matter to these Tory bastards.
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Post by chigstoke on Nov 30, 2020 17:25:56 GMT
That screams to me that the government are in businesses ears telling them what they can and can’t enforce. They can say the vaccines aren’t mandatory all they want, but you can bet your bottom fucking dollar your liberties will be extremely restricted if you don’t have it. This isn’t me saying it’s a pure evil vaccine that will alter your DNA or whatever, but it’s just control. They’re loving every minute of it. |
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Post by chigstoke on Nov 30, 2020 17:31:57 GMT
Newcastle, Stafford and East and South Staffs are all below 300. Fingers crossed Stoke-on-Trent will follow next week. Not that it will matter to these Tory bastards. Hopefully so. I don't trust that lot one fucking jot though. The amount of businesses on the brink must be an unbelievable and frightening number. Not just in our city but all over the country. |
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Post by crouchpotato1 on Nov 30, 2020 17:52:40 GMT
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Post by Paul Spencer on Nov 30, 2020 17:58:02 GMT
Not directly Covid related, but absolutely huge news coming out in the world of AI today. DeepMind AI has successfully predicted the structure of proteins to atom width degree of accuracy based on just the amino acid sequence alone. This is like being able to predict how 500 random bits of lego will form together to form a structure based on how you have lined them up. This has massive ramifications for things like drug development, with things like this we will be able to feasibly predict how proteins go wrong in disease structurally , and design novel compounds and drugs accordingly to try and reverse these changes. Aberrant protein folding is a massive cause of neurodegenerative and cancer conditions but is basically a major cause of disease in a variety of contexts. We can now predict what a very tiny mutation in DNA sequence will now have on amino acid sequence and subsequently how this changes the function of a protein. They are now starting work with some parasitic diseases where the parasites evade the immune system by changing their protein coats. Amazing stuff. www.google.co.uk/amp/s/techcrunch.com/2020/11/30/alphabets-deepmind-achieves-historic-new-milestone-in-ai-based-protein-structure-prediction/amp/Matt, what are your thoughts on the short video below, where Professor Luke O'Neill is caught off guard? Many thanks |
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Post by estrangedsonoffaye on Nov 30, 2020 18:10:35 GMT
Not directly Covid related, but absolutely huge news coming out in the world of AI today. DeepMind AI has successfully predicted the structure of proteins to atom width degree of accuracy based on just the amino acid sequence alone. This is like being able to predict how 500 random bits of lego will form together to form a structure based on how you have lined them up. This has massive ramifications for things like drug development, with things like this we will be able to feasibly predict how proteins go wrong in disease structurally , and design novel compounds and drugs accordingly to try and reverse these changes. Aberrant protein folding is a massive cause of neurodegenerative and cancer conditions but is basically a major cause of disease in a variety of contexts. We can now predict what a very tiny mutation in DNA sequence will now have on amino acid sequence and subsequently how this changes the function of a protein. They are now starting work with some parasitic diseases where the parasites evade the immune system by changing their protein coats. Amazing stuff. www.google.co.uk/amp/s/techcrunch.com/2020/11/30/alphabets-deepmind-achieves-historic-new-milestone-in-ai-based-protein-structure-prediction/amp/Matt, what are your thoughts on the short video below? Many thanks Phase 4 trials are almost always undertaken once the vaccine or drug is licensed for use, there’s nothing remotely unusual about that. This is because of the numbers (hundreds of thousands to millions) involved in rollout that will pick up the ultra-rare side effects (such as those on a paracetamol information sheet) and any rare long term effects that can’t be picked up in Phase 3. It’s called pharmacovigilance. www.google.co.uk/amp/s/amp.cancer.org/treatment/treatments-and-side-effects/clinical-trials/what-you-need-to-know/phases-of-clinical-trials.htmlThe reason Phase 3 safety data only lasts up to 2-3 months is because the overwhelming majority of side effects occur within this period. |
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Post by werrington on Nov 30, 2020 18:18:45 GMT
Only THREE hospitals are busier than they were last winter, data shows mol.im/a/9000935 |
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Post by hcstokie on Nov 30, 2020 18:20:07 GMT
I don’t think it will come to that. The lawyers will be queuing up to file a data protection and discrimination lawsuit against the first business that requests a customers medical history in order to let them into the store. Does it fundamentally differ from say how airlines can refuse passage to anyone wishing to board a flight drunk on the premise they may be a danger to other passengers? No one will want to sit in a confined space for 13 hours down to Singapore sat next to some herbert blowing neat covid out of every orifice since he has refused a vaccine will they? To anyone who does I'd say 'you first' and pick another airline. There’s a difference between someone who’s chosen to get pissed up compared to someone who chooses not to have a vaccine based on their personal beliefs. There’s no difference between someone refusing to have a jab for COVID compared to someone choosing not to be vaccinated for any other disease. If everyone else on the flight has been vaccinated then what’s the issue? The only real material risk is someone passing it on to other people who’ve refused a vaccine and that’s obviously a risk they’re willing to take. I’ll be having the jab as soon as it’s offered but people shouldn’t be refused access to services / privileges if they’ve refused it. People need to assess risk and act accordingly. I flew in September and felt safe. I’d feel even safer knowing I’d had a jab, but you can’t control everyone and expect everyone to think and act the same. |
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Post by CBUFAWKIPWH on Nov 30, 2020 18:26:28 GMT
The timing of this wave suggests that children/students going back were the trigger (and that the virus is predominantly seasonal) and its this link which has spread the disease through out households. Whilst this link is open, you could argue that the lock downs did/do bugger all/little to suppress the virus and it simply ran through the young until enough immunity was there for transmission to fall. Meanwhile the hospitality sector has been hung out to dry like some sort of sacrificial lamb. That simply isn't true. No age group is anywhere near herd immunity and anyway age related herd immunity isn't a thing if generations mix - which they will because any form of age apartheid would be impossible to implement. The original tier 2 restrictions didn't bring transmissions under control - tier 3 and the recent national restrictions did. The government have tightened up the rules for the new tier 2 because this is the evidence was that the original tier 2 was just a conveyor belt into tier 3. Every country in the world that has implemented a a sufficiently stringent lock down have seen infections and deaths fall and when restrictions have loosened infections and deaths have gone up in subject to the underlying seasonal variation. There are certainly other problems associated with lock downs but to argue they don't work is nonsense - providing the rules are strict enough. |
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Post by crouchpotato1 on Nov 30, 2020 18:29:37 GMT
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Post by duckling on Nov 30, 2020 18:45:20 GMT
If everyone else on the flight has been vaccinated then what’s the issue? The only real material risk is someone passing it on to other people who’ve refused a vaccine and that’s obviously a risk they’re willing to take. This argument, used a lot by anti-vaccine people, is flawed. The vaccine is at best 95% effective. That's still 1 out of every 20 vaccinated people who are vulnerable to getting the virus. In addition, there are people who can't be vaccinated. Two examples are pregnant women and people with certain underlying health problems. I am desperate to get the vaccine because I'm immunosuppressed, but it is precisely that vulnerable health state that may render me unable to get the vaccine. I'll have to speak with my immunologist. People who have medical problems such as a compromised immune system are at high risk of severe complications from Covid. They rely on others getting vaccinated because they can't. There has been talk in this thread and elsewhere about shielding the vulnerable. The best way to shield the vulnerable is for people who can get the vaccine to get it. |
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Post by starkiller on Nov 30, 2020 18:47:09 GMT
One 'nudge' at a time. The totalitarian tiptoe.
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Post by hcstokie on Nov 30, 2020 18:55:52 GMT
If everyone else on the flight has been vaccinated then what’s the issue? The only real material risk is someone passing it on to other people who’ve refused a vaccine and that’s obviously a risk they’re willing to take. This argument, used a lot by anti-vaccine people, is flawed. The vaccine is at best 95% effective. That's still 1 out of every 20 vaccinated people who are vulnerable to getting the virus. In addition, there are people who can't be vaccinated. Two examples are pregnant women and people with certain underlying health problems. I am desperate to get the vaccine because I'm immunosuppressed, but it is precisely that vulnerable health state that may render me unable to get the vaccine. I'll have to speak with my immunologist. People who have medical problems such as a compromised immune system are at high risk of severe complications from Covid. They rely on others getting vaccinated because they can't. There has been talk in this thread and elsewhere about shielding the vulnerable. The best way to shield the vulnerable is for people who can get the vaccine to get it. I appreciate your point and hope that when the time comes you can get it. The point I’m trying to make is that a balance has to be struck between risk and people’s freedom of choice. If the argument is taken to the extreme are we suggesting that anyone who doesn’t or can’t take the vaccine should never be allowed to leave their home for fear of being infected or being infectious themselves? |
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Post by scfcbiancorossi on Nov 30, 2020 19:03:07 GMT
Newcastle, Stafford and East and South Staffs are all below 300. Fingers crossed Stoke-on-Trent will follow next week. Not that it will matter to these Tory bastards. Or the Labour bastards Dave. Let's not let them off the hook. At least some Tory mps are voting these cretins down. Sadly I suspect there will be zero Labour mps voting it down. Our Parliament is an utter disgrace from top to bottom. |
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Post by RedandWhite90 on Nov 30, 2020 19:09:04 GMT
One 'nudge' at a time. The totalitarian tiptoe. Would it help if they give you a sticker or a stamp after having the injection? |
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Post by starkiller on Nov 30, 2020 19:24:23 GMT
One 'nudge' at a time. The totalitarian tiptoe. Would it help if they give you a sticker or a stamp after having the injection? You're going to get a health, or 'freedom' pass. Likely on your phone, for now. And, as I've said before, once people accept a pass for simply doing normal everyday stuff, it's the end of human freedom forever. It's a control pass. Potential for more stuff to be added, including, eventually, your social credit score. This, apparently, all for a virus with nearly 100% survival. Yeah... course it is... |
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Post by RedandWhite90 on Nov 30, 2020 19:38:50 GMT
Would it help if they give you a sticker or a stamp after having the injection? You're going to get a health, or 'freedom' pass. Likely on your phone, for now. And, as I've said before, once people accept a pass for simply doing normal everyday stuff, it's the end of human freedom forever. It's a control pass. Potential for more stuff to be added, including, eventually, your social credit score. This, apparently, all for a virus with nearly 100% survival. Yeah... course it is... I know I shouldn't but I cannot resist, can you explain what my social credit score is? Is it like experian but based on how many mates I've got or not got? |
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Post by Gods on Nov 30, 2020 19:41:41 GMT
Does it fundamentally differ from say how airlines can refuse passage to anyone wishing to board a flight drunk on the premise they may be a danger to other passengers? No one will want to sit in a confined space for 13 hours down to Singapore sat next to some herbert blowing neat covid out of every orifice since he has refused a vaccine will they? To anyone who does I'd say 'you first' and pick another airline. There’s a difference between someone who’s chosen to get pissed up compared to someone who chooses not to have a vaccine based on their personal beliefs. There’s no difference between someone refusing to have a jab for COVID compared to someone choosing not to be vaccinated for any other disease. If everyone else on the flight has been vaccinated then what’s the issue? The only real material risk is someone passing it on to other people who’ve refused a vaccine and that’s obviously a risk they’re willing to take. I’ll be having the jab as soon as it’s offered but people shouldn’t be refused access to services / privileges if they’ve refused it. People need to assess risk and act accordingly. I flew in September and felt safe. I’d feel even safer knowing I’d had a jab, but you can’t control everyone and expect everyone to think and act the same. That's not quite true if vaccines are circa 90% effective is it? Lots of countries require certain vaccines in order to visit today. |
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Post by starkiller on Nov 30, 2020 19:41:42 GMT
You're going to get a health, or 'freedom' pass. Likely on your phone, for now. And, as I've said before, once people accept a pass for simply doing normal everyday stuff, it's the end of human freedom forever. It's a control pass. Potential for more stuff to be added, including, eventually, your social credit score. This, apparently, all for a virus with nearly 100% survival. Yeah... course it is... I know I shouldn't but I cannot resist, can you explain what my social credit score is? Is it like experian but based on how many mates I've got or not got? |
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Post by crouchpotato1 on Nov 30, 2020 19:54:38 GMT
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Post by Paul Spencer on Nov 30, 2020 19:55:42 GMT
Matt, what are your thoughts on the short video below? Many thanks Phase 4 trials are almost always undertaken once the vaccine or drug is licensed for use, there’s nothing remotely unusual about that. This is because of the numbers (hundreds of thousands to millions) involved in rollout that will pick up the ultra-rare side effects (such as those on a paracetamol information sheet) and any rare long term effects that can’t be picked up in Phase 3. It’s called pharmacovigilance. www.google.co.uk/amp/s/amp.cancer.org/treatment/treatments-and-side-effects/clinical-trials/what-you-need-to-know/phases-of-clinical-trials.htmlThe reason Phase 3 safety data only lasts up to 2-3 months is because the overwhelming majority of side effects occur within this period. Great answer mate, many thanks. |
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Post by werrington on Nov 30, 2020 20:00:58 GMT
Gutless twats That abstain nonsense should be outlawed and they should be forced to make a decision |
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Post by duckling on Nov 30, 2020 20:02:37 GMT
This argument, used a lot by anti-vaccine people, is flawed. The vaccine is at best 95% effective. That's still 1 out of every 20 vaccinated people who are vulnerable to getting the virus. In addition, there are people who can't be vaccinated. Two examples are pregnant women and people with certain underlying health problems. I am desperate to get the vaccine because I'm immunosuppressed, but it is precisely that vulnerable health state that may render me unable to get the vaccine. I'll have to speak with my immunologist. People who have medical problems such as a compromised immune system are at high risk of severe complications from Covid. They rely on others getting vaccinated because they can't. There has been talk in this thread and elsewhere about shielding the vulnerable. The best way to shield the vulnerable is for people who can get the vaccine to get it. I appreciate your point and hope that when the time comes you can get it. The point I’m trying to make is that a balance has to be struck between risk and people’s freedom of choice. If the argument is taken to the extreme are we suggesting that anyone who doesn’t or can’t take the vaccine should never be allowed to leave their home for fear of being infected or being infectious themselves? If there isn't adequate voluntary vaccination to stop the spread, then yes, I think some degree of mandatory vaccination in the general population will be needed to go anywhere without restrictions. I think anyone with direct contact with vulnerable people, such as healthcare and care home workers, should be subject to mandatory vaccination unless they are exempted for medical reasons. In terms of the rest of the population, I hope it doesn't come to that, but I wouldn't be opposed to mandatory vaccination. If people were as resistant to the polio vaccine as they are to vaccines today, we would still be dealing with polio outbreaks. Polio killed FAR fewer people per year compared with Covid. In the United States, the most polio deaths in a single year was around 6000. Serious neurological problems occurred in 0.5% and were permanent in 0.01%. The vast majority of people had only mild symptoms. Sound familiar? |
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Post by Clem Fandango on Nov 30, 2020 20:04:31 GMT
Gutless twats That abstain nonsense should be outlawed and they should be forced to make a decision its the voting equvialent of 'I couldn't give a fuck what you do' have some balls and make a decison |
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Post by chad on Nov 30, 2020 20:09:20 GMT
Gutless twats That abstain nonsense should be outlawed and they should be forced to make a decision its the voting equvialent of 'I couldn't give a fuck what you do' have some balls and make a decison So having lost an election because they sat on the fence over Brexit here they go again Moan moan and whinge about everything. Much easier than actually making decisions |
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Post by chigstoke on Nov 30, 2020 20:11:46 GMT
God we have an horrendous bunch of politicians inhabiting the country.
They can shove their abstain right up their fucking rectums.
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Post by hcstokie on Nov 30, 2020 20:15:37 GMT
I appreciate your point and hope that when the time comes you can get it. The point I’m trying to make is that a balance has to be struck between risk and people’s freedom of choice. If the argument is taken to the extreme are we suggesting that anyone who doesn’t or can’t take the vaccine should never be allowed to leave their home for fear of being infected or being infectious themselves? If there isn't adequate voluntary vaccination to stop the spread, then yes, I think some degree of mandatory vaccination in the general population will be needed to go anywhere without restrictions. I think anyone with direct contact with vulnerable people, such as healthcare and care home workers, should be subject to mandatory vaccination unless they are exempted for medical reasons. In terms of the rest of the population, I hope it doesn't come to that, but I wouldn't be opposed to mandatory vaccination. If people were as resistant to the polio vaccine as they are to vaccines today, we would still be dealing with polio outbreaks. By the way, polio killed FAR fewer people per year compared with Covid. In the United States, the most polio deaths in a single year was around 6000. I could be wrong but after the impact on our lives this year I believe that people will be queuing up for the vaccine. I’ll be in line as soon as it’s offered. I’d hope that the people refusing to have it will be few and far between. Mandatory vaccination doesn’t sit well with me as it should be optional. What really doesn’t sit well with me is the suggestion that eating, drinking and shopping establishments may ask people to disclose their medical history prior to admission. |
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Post by crouchpotato1 on Nov 30, 2020 20:16:59 GMT
Gutless twats That abstain nonsense should be outlawed and they should be forced to make a decision The state of Politics in this country I’m afraid mate,all fuckin useless |
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Post by werrington on Nov 30, 2020 20:17:09 GMT
Gutless twats That abstain nonsense should be outlawed and they should be forced to make a decision its the voting equvialent of 'I couldn't give a fuck what you do' have some balls and make a decison It’s a serious subject about something that affects every single person in the entire country and they can’t be arsed to make a decision on it and vote either way It’s nothing short of a national disgrace |
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Post by andystokey on Nov 30, 2020 20:17:20 GMT
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