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Post by felonious on Mar 31, 2024 15:09:37 GMT
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Post by iancransonsknees on Mar 31, 2024 15:14:16 GMT
So Lizzo's part Labrador then? Along with 75% of the rest of America and 60% of Brits? |
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Post by felonious on Mar 31, 2024 17:51:37 GMT
So Lizzo's part Labrador then? Along with 75% of the rest of America and 60% of Brits? It's a fascinating subject as to whether humans are "hard wired for obesity" On the subject of obesity I occasionally visit Bod in Alsager for lunch alongside Gnasher. He's happily munching on low fat small treats although there's not an ounce of fat on him because of the amount of exercise he gets. Because of the time of day there are hundreds of students from Alsager School on the other side of the road heading to the Lakeside fish bar and further on to Asda to get some lunch. I kid you not, not a one of them is overweight even the ones stuffing a plate of chips down their throats. Perhaps Cambridge should be studying the "Alsager gene"  |
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Post by thehartshillbadger on Mar 31, 2024 18:45:17 GMT
I used to have a Great Dane, it could polish a pint of Guinness off in two seconds flat. I think I may have the Great Dane gene unfortunately
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Post by cvillestokie on Mar 31, 2024 23:28:24 GMT
So Lizzo's part Labrador then? Along with 75% of the rest of America and 60% of Brits? It's a fascinating subject as to whether humans are "hard wired for obesity" On the subject of obesity I occasionally visit Bod in Alsager for lunch alongside Gnasher. He's happily munching on low fat small treats although there's not an ounce of fat on him because of the amount of exercise he gets. Because of the time of day there are hundreds of students from Alsager School on the other side of the road heading to the Lakeside fish bar and further on to Asda to get some lunch. I kid you not, not a one of them is overweight even the ones stuffing a plate of chips down their throats. Perhaps Cambridge should be studying the "Alsager gene" I personally think that it’s a bit of a get out clause to be honest. It’s incredibly well funded not because so many have a strong genetic predisposition to obesity, but because the opportunity to develop a pill that would allow people to continue with their poor habits while losing weight is incredibly exciting to Pharma. SNPs in the FTO region have been studied since the advent of the GWAS era. However, the vast majority of the risk associated with these SNPs are minimal (10-30% increased risk for obesity). They have also been shown to be largely attenuated in physically active adults. Some people may find losing weight harder than others. However, older people suffer from a slowing in metabolism. Not all old people are fat because of it. They just have to change their habits. |
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Post by gawa on Apr 1, 2024 2:41:35 GMT
I used to have a Great Dane, it could polish a pint of Guinness off in two seconds flat. I think I may have the Great Dane gene unfortunately Sounds more like an Irish wolfhound to me. Great big dogs. |
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Post by elystokie on Apr 1, 2024 5:35:48 GMT
I used to have a Great Dane, it could polish a pint of Guinness off in two seconds flat. I think I may have the Great Dane gene unfortunately Watched that bald Greg fella on the telly go around the Guinness brewery not long back. Apparently the difference between Guinness and beer is that they roast the barley. Can't help but wonder how that makes it healthier, as is widely believed 🤔 |
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Post by salopstick on Apr 1, 2024 6:58:23 GMT
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Post by xchpotter on Apr 1, 2024 8:07:17 GMT
Tell us something we didn’t know about labs 😂. I’ve yet to meet one who doesn’t scoff anything(inedible also counts) in front of them….but they are gorgeous.
On a serious note and humans, there is a genetic condition called Prader-Willi syndrome which is a genetic mutation and causes these exact issues with hunger. It comes with other learning disabilities as well and is the condition that Katey Price’s son Harvey has. Imagine being hungry all of the time and never feeling full….food is your life.
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Post by felonious on Apr 2, 2024 17:33:02 GMT
It's a fascinating subject as to whether humans are "hard wired for obesity" On the subject of obesity I occasionally visit Bod in Alsager for lunch alongside Gnasher. He's happily munching on low fat small treats although there's not an ounce of fat on him because of the amount of exercise he gets. Because of the time of day there are hundreds of students from Alsager School on the other side of the road heading to the Lakeside fish bar and further on to Asda to get some lunch. I kid you not, not a one of them is overweight even the ones stuffing a plate of chips down their throats. Perhaps Cambridge should be studying the "Alsager gene" I personally think that it’s a bit of a get out clause to be honest. It’s incredibly well funded not because so many have a strong genetic predisposition to obesity, but because the opportunity to develop a pill that would allow people to continue with their poor habits while losing weight is incredibly exciting to Pharma. SNPs in the FTO region have been studied since the advent of the GWAS era. However, the vast majority of the risk associated with these SNPs are minimal (10-30% increased risk for obesity). They have also been shown to be largely attenuated in physically active adults. Some people may find losing weight harder than others. However, older people suffer from a slowing in metabolism. Not all old people are fat because of it. They just have to change their habits. Thanks for that if I'm understanding those acronyms correctly it ties in with the assertion in the article that Labradors don't need to be fat |
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Post by cvillestokie on Apr 2, 2024 20:56:25 GMT
I personally think that it’s a bit of a get out clause to be honest. It’s incredibly well funded not because so many have a strong genetic predisposition to obesity, but because the opportunity to develop a pill that would allow people to continue with their poor habits while losing weight is incredibly exciting to Pharma. SNPs in the FTO region have been studied since the advent of the GWAS era. However, the vast majority of the risk associated with these SNPs are minimal (10-30% increased risk for obesity). They have also been shown to be largely attenuated in physically active adults. Some people may find losing weight harder than others. However, older people suffer from a slowing in metabolism. Not all old people are fat because of it. They just have to change their habits. Thanks for that if I'm understanding those acronyms correctly it ties in with the assertion in the article that Labradors don't need to be fat Pretty much. I mean, it’s the owner that feeds them. They could walk them more and feed them less. In the case of Prader-Willi mentioned above, this a different type of genetic disease. Genetic variants (single nucleotide polymorphisms (SNPs)) that have really large effect sizes are rare. Prader-Willi is caused by a large scale chromosomal deletion - it’s even more rare. The reason why these big effect size changes are rare is because they are not evolutionarily advantageous and so they get selected against. Something that is incredibly common in the population is unlikely to have a huge negative effect because if it did, these animals wouldn’t compete well. |
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