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Post by musik on Jul 3, 2023 22:59:32 GMT
Regenerative medicine, a fascinating field and a hobby of mine. Not that I do some weekend surgery now and then, but I do read about it, research articles and so on.
It would be awesome if the trials with camera connectivity to the optic nerve in blind people had an enough positive outcome some years ago so it was worthwhile to continue that research. But I haven't heard anything. The idea was to put a tiny camera to one side of the head under the blind person's skin, connected to the optic nerve. And what about the hearing cells they tried to grow in a lab many years ago? There my interest started.
On the rise lately has been the brain stimulation surgery debate where they try to reverse what happens when epilepsy, Parkinson, drug abuse and other difficult conditions occur. Ultrasound might be effective as well, at least in theory. But it's within brain stimulation by electrodes and the destroying of bad brain areas they have succeeded the most so far.
Warning signs light up of course, since we have the grey or black zone, where voices talk about changing sexual behaviour, thoughts, needs and so on. Criminality and sexuality variations have been said to show different scans on an individual level compared to what's seen as normal. And there are quite a few out there who wants to act, not to mention dictators. It's of vital importance people act quick before it's too late! That's my concern.
Regenerative medicine will expand quickly, in particular with the help from AI, and hopefully it's done correctly and as a servant for the human race.
Nevertheless, fascinating times to come. I'm pretty sure they will cure many things in the not that far future.
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Post by mtrstudent on Jul 4, 2023 17:08:41 GMT
Can they only regrow what you had, or are they gonna give you some "enhancements" too?
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Post by musik on Jul 4, 2023 18:51:03 GMT
Can they only regrow what you had, or are they gonna give you some "enhancements" too? Regrowth? They are not completely there yet, but they will. It's a very complex world our body, but definitely the most fascinating one. I'm pretty sure I would do research within regenerative medicine if I got another life. There are some promising results out there. But there is always a long process going from the idea, scientific theory and plan on what to achieve, to the clinical experimental tests within the study and finally the production of an end product, which in the case of stem cell therapy for instance often actually is a method. From what I've heard they make progress almost on a daily basis now. And the 3-d printing of body parts(!) is another fascinating field. But I've only started to read about this. They actually believe they some time will be able to reproduce any or almost any body part. The brain too? 🤔 I don't know. When it comes to joints and cartilage they work with substitute materials to see what could replace the cartilage in the future. Surprisingly, I was told it has never been so much research going on within that field. On the other hand, from what I understand these related diseases cost societies huge amounts amounts of money, perhaps most of all kinds of diseases. Enhancements? I can speak for myself and obviously there is no need for that ... But when it comes to enhancements in general actually we move towards the ethical debate. There are worries some states will try to "enhance" people to some extent. Maybe a dictator who doesn't like people with blonde or black hair or another dictator who would like to produce people without emotions for military purposes. Interesting is though, with enhancement stem cells therapy (if such a thing occur), you could imagine plastic surgery being replaced. Mainly because stem cells therapy is often an invasive method, which normal surgery obviously isn't in many cases. Keep in mind though that one of the big challenges with stem cell therapy is to avoid the mutation of cells to cancer cells. And cancer is a growth, so to make an enhancement (growth) without some of them turning into cancer is very risky and difficult. However, if it continues I wouldn't be surprised a human could live several hundred years. Maybe be immortal in the end. What kind of pension system will we have then? 🤠
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Post by mtrstudent on Jul 4, 2023 19:42:27 GMT
Keep in mind though that one of the big challenges with stem cell therapy is to avoid the mutation of cells to cancer cells. And cancer is a growth, so to make an enhancement (growth) without some of them turning into cancer is very risky and difficult. However, if it continues I wouldn't be surprised a human could live several hundred years. Maybe be immortal in the end. What kind of pension system will we have then? 🤠 Hadn't thought about the cancer issue, sounds even trickier than I thought. Would it be good to live hundreds of years? Would you keep getting crankier though?
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Post by musik on Jul 4, 2023 20:37:31 GMT
Keep in mind though that one of the big challenges with stem cell therapy is to avoid the mutation of cells to cancer cells. And cancer is a growth, so to make an enhancement (growth) without some of them turning into cancer is very risky and difficult. However, if it continues I wouldn't be surprised a human could live several hundred years. Maybe be immortal in the end. What kind of pension system will we have then? 🤠 Hadn't thought about the cancer issue, sounds even trickier than I thought. Would it be good to live hundreds of years? Would you keep getting crankier though? Crankier, you mean avoiding dementia or not. I would suppose they take the dementia risk factor into the calculation, and with brain treatment somewhere along the way. What's the point otherwise, since we basically ARE our brains. Some theorists say silicon may be the element for the solution. The skin is another factor. What would happen? And the skin isn't just a covering "sheet", it has functions, what will happen with them? The best way to experience this new research world in the future for sure anyway, would most likely be to consider cryonics. To be placed in Alcor, Arizona, in a tube at -196°C after the death. Then after more than a hundred, perhaps after 200 years be shaken to woke up in a different time. I've seriously thought about that!
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Post by musik on Jul 4, 2023 21:11:20 GMT
www.swissmedica.orgThat's a website about different already existing clinical treatments within a fascinating field. Note: I have no experience from swissmedica myself and no intention of advertising anything whatsoever. I just wanted to present a website where you can see new medical research is being transformed into treatment alternatives clinically.
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Post by musik on Jul 5, 2023 5:55:49 GMT
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Post by musik on Jul 5, 2023 6:01:37 GMT
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Post by musik on Jul 5, 2023 8:13:30 GMT
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Post by musik on Jul 5, 2023 8:18:23 GMT
Better than the current drug war? It's all about freeing the reward system from the memory.
New fact, stem cells originating in the placenta can reach damaged tissue in the brains of drug addicts and initiate a rehabilitation process.
This fantastic development of a treatment based on placenta cells may solve one of the most formidable challenges in the field of detoxification: the difficulty of addicts to disconnect from the memory that brings them back again and again to the drug.
To good to be true it seems, but a non-invasive treatment without drug substitutes, based on placenta-derived stem cells, offers an innovative and safe approach to the treatment of drug addiction and rehabilitation following withdrawal. The treatment, first after a pre-clinical trial and then awaiting a human trial, succeeds in overcoming one of the biggest challenges in the field of addictions: addicts have difficulty breaking away from the initial “sweet” memory that makes them return to the drug, even if they know that the same substance makes them miserable.
This is the reality that led Prof. Yadid to develop an innovative targeted treatment, which focuses on freeing the reward system from the memory of the drug, which leads to the addict’s compulsive behavior. The researchers turned to treatment with the help of stem cell transplantation, an approach that is safe, with no side effects, and already well known for the treatment of other diseases.
The study was published in the Pharmaceutics journal and shows that neurogenesis (formation of new brain cells) is restored at a high level of 95%. It is the flexibility of the stem cells which allows them to build new, healthy tissue in the place to which they have migrated. Cell tracking was performed by linking the cells to gold nanoparticles. The gold makes it possible to follow the migration of the cells using a CT scanner.
The study was funded by the National Institute on Drug Abuse, which is part of the National Institutes of Health.
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Post by elystokie on Jul 5, 2023 8:37:28 GMT
Research conducted at Bar-Ilan University’s Gonda Multidisciplinary Brain Research Center shows that stem cells originating in the placenta can reach damaged tissue in the brains of drug addicts and initiate a rehabilitation process. The development of a treatment based on placenta cells may solve one of the most formidable challenges in the field of detoxification: the difficulty of addicts to disconnect from the memory that brings them back again and again to the drug. The research is led by Prof. Gal Yadid and PhD student Hilla Pe’er-Nissan of BIU’s Goodman Faculty of Life Sciences and Gonda Multidisciplinary Brain Research Center. A non-invasive treatment without drug substitutes, based on placenta-derived stem cells, offers an innovative and safe approach to the treatment of drug addiction and rehabilitation following withdrawal. The treatment, currently after a pre-clinical trial and awaiting a human trial, succeeds in overcoming one of the biggest challenges in the field of addictions: addicts have difficulty breaking away from the initial “sweet” memory that makes them return to the drug, even if they know that the same substance makes them miserable. The treatment allows the brain to create new memory cells that assimilate new memories that compete with the "addictive memory". Prof. Yadid describes himself as a “frustrated neuro-psycho-pharmacologist”. His frustration stems from the fact that the medicinal treatments available today for people suffering from addictions do not provide a viable solution: 30% of patients drop out within three months of starting rehabilitation, and of those who complete the rehabilitation program, about 50% return to drugs. These people, who do not respond well to treatment, endure constant suffering and are at greater risk for suicide. In addition, this ongoing situation causes a heavy familial, social, and economic burden. This is the reality that led Prof. Yadid to develop an innovative targeted treatment, which focuses on freeing the reward system from the memory of the drug, which leads to the addict’s compulsive behavior. The researchers turned to treatment with the help of stem cell transplantation, an approach that is safe, with no side effects, and already well known for the treatment of other diseases. Moreover, the innovation in the work of Prof. Yadid and collaborators is that the stem cells are administered intranasally (via inhalation), which brings them directly to the brain. This method allows precision in reaching the targeted tissue that was damaged by drug use, as well as real time monitoring using CT scanning, all without dangerous substances or drug substitutes. The stem cells inhaled by the subject navigate their way through the brain and settle in the damaged areas. The load they carry, which includes growth factors, leads both to the restoration of the damaged cells, which do not release nerve messengers at the right rate, and to restored connectivity. The stem cells know to settle where the brain needs them the most, and Prof. Yadid believes that this is chemical communication. The cells “smell” where their help is needed and reach the damaged tissue. “We actually have a ‘mail pigeon’. I can send with it any payload that is needed,” explains Prof. Yadid. After completing their mission in the damaged tissue, the stem cells migrate to another damaged site, or die and leave the body. The ability to navigate and nest in the right place makes the treatment safe, without the concern that the stem cell will settle in an area that is not associated with the addiction and cause side effects. The study, published in the Pharmaceutics journal, shows that neurogenesis (formation of new brain cells) is restored at a level of 95%. It is the flexibility of the stem cells which allows them to build new, healthy tissue in the place to which they have migrated. Cell tracking was performed by linking the cells to gold nanoparticles. The gold makes it possible to follow the migration of the cells from the moment of inhalation until they reach the brain, using a CT scanner. The researchers saw that it takes a day for the cells to reach the specific brain regions, and the tissue restoration process lasts several days. Beyond the introduction of gold nanoparticles, no further manipulation was performed on the cells, so it is a completely natural treatment. “Since these cells have already been tested on patients with other diseases, and with a high level of safety, we hope that the next stage is to treat addicts who have not been successful in quitting,” Prof. Yadid concludes. The study conducted by Prof. Yadid and his collaborators – The Pluristem Therapeutics Inc. led by Dr. Racheli Ofir, and the laboratory of Prof. Rachela Popovtzer and Dr. Oshra Betzer – was funded by the National Institute on Drug Abuse, which is part of the National Institutes of Health. The more available treatments available the better, hopefully this will give hope to more people and potentially reduce the customer base of the criminal cartels (removing prohibition would also help with this). 'Prof. Yadid describes himself as a “frustrated neuro-psycho-pharmacologist”.' - might be good if he could collaborate with Professor David Nutt in the UK and Professor Carl Hart in the USA, both are neuropsychopharmacologists with many studies and a few books each on the subject of drugs and addiction.
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Post by musik on Jul 5, 2023 9:08:37 GMT
The more available treatments available the better, hopefully this will give hope to more people and potentially reduce the customer base of the criminal cartels (removing prohibition would also help with this). 'Prof. Yadid describes himself as a “frustrated neuro-psycho-pharmacologist”.' - might be good if he could collaborate with Professor David Nutt in the UK and Professor Carl Hart in the USA, both are neuropsychopharmacologists with many studies and a few books each on the subject of drugs and addiction. I'm not a conspiracy theorist but I'm pretty convinced about the Covid-19 vaccination, in some countries you were practically forced to take it. And now I'm not only talking about losing your job otherwise ... The same will happen with this in a few years. If you are a heavy user or a light user of any type of drug you will be forced to undergo this treatment in certain places of the planet. So basically yes, there won't be any need for a drug cartel customer base then. And these cities or states will show the stats to the rest of the world. And more will follow ... with the separation of the reward system of the brain. What happens with the human race then? Don't we have a reward system for a reason? What would the side effects be? So we must beware, and not swallow everything just because it's new, stem cells or AI ...
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Post by elystokie on Jul 5, 2023 9:15:17 GMT
The more available treatments available the better, hopefully this will give hope to more people and potentially reduce the customer base of the criminal cartels (removing prohibition would also help with this). 'Prof. Yadid describes himself as a “frustrated neuro-psycho-pharmacologist”.' - might be good if he could collaborate with Professor David Nutt in the UK and Professor Carl Hart in the USA, both are neuropsychopharmacologists with many studies and a few books each on the subject of drugs and addiction. I'm not a conspiracy theorist but I'm pretty convinced about the Covid-19 vaccination, in some countries you were practically forced to take it. And now I'm not only talking about losing your job otherwise ... The same will happen with this in a few years. If you are a heavy user or a light user of any type of drug you will be forced to undergo this treatment in certain places of the planet. So basically yes, there won't be any need for a drug cartel customer base then. And these cities or states will show the stats to the rest of the world. And more will follow ... with the separation of the reward system of the brain. What happens with the human race then? Don't we have a reward system for a reason? What would the side effects be? So we must beware, and not swallow everything just because it's new, stem cells or AI ... Totally agree with your last paragraph, obviously. As for the rest, the USA has been moving further and further away from drug prohibition in recent years, it would take a massive paradigm shift to implement this forced treatment and it certainly wouldn't meet with the approval of two of the world's most eminent neuropsychopharmacologists.
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Post by maninasuitcase on Jul 5, 2023 12:24:00 GMT
Sounds like the film Limitless.
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Post by musik on Jul 5, 2023 14:50:03 GMT
Sounds like the film Limitless. Now you're touching Enhancements, which mtrstudent did earlier. But regenerative medicine is nothing like that. It's about getting back lost functions basically, lost by injuries and severe diseases.
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Post by musik on Jul 5, 2023 16:27:38 GMT
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Post by mrrine on Jul 5, 2023 20:40:12 GMT
Wonder what the total cost is.
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Post by gawa on Jul 5, 2023 20:47:56 GMT
I'm not a conspiracy theorist but I'm pretty convinced about the Covid-19 vaccination, in some countries you were practically forced to take it. And now I'm not only talking about losing your job otherwise ... The same will happen with this in a few years. If you are a heavy user or a light user of any type of drug you will be forced to undergo this treatment in certain places of the planet. So basically yes, there won't be any need for a drug cartel customer base then. And these cities or states will show the stats to the rest of the world. And more will follow ... with the separation of the reward system of the brain. What happens with the human race then? Don't we have a reward system for a reason? What would the side effects be? So we must beware, and not swallow everything just because it's new, stem cells or AI ... Totally agree with your last paragraph, obviously. As for the rest, the USA has been moving further and further away from drug prohibition in recent years, it would take a massive paradigm shift to implement this forced treatment and it certainly wouldn't meet with the approval of two of the world's most eminent neuropsychopharmacologists. The biggest drug people are addicted to and that costs the most lives in the US is alcohol. I really can't see the big alcohol and nightlife companies wanting something like this pushed through. It sounds a great drug though which could be revolutionary.
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Post by elystokie on Jul 5, 2023 21:06:44 GMT
Totally agree with your last paragraph, obviously. As for the rest, the USA has been moving further and further away from drug prohibition in recent years, it would take a massive paradigm shift to implement this forced treatment and it certainly wouldn't meet with the approval of two of the world's most eminent neuropsychopharmacologists. The biggest drug people are addicted to and that costs the most lives in the US is alcohol. I really can't see the big alcohol and nightlife companies wanting something like this pushed through. It sounds a great drug though which could be revolutionary. It does, be great if it works and the side effects are negligible, it's just the 'forced' thing I can't see happening unless it's offered as an alternative to a custodial sentence or something similar.
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Post by musik on Jul 5, 2023 21:08:13 GMT
Wonder what the total cost is. Me too.
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Post by musik on Jul 5, 2023 21:09:40 GMT
The biggest drug people are addicted to and that costs the most lives in the US is alcohol. I really can't see the big alcohol and nightlife companies wanting something like this pushed through. It sounds a great drug though which could be revolutionary. It does, be great if it works and the side effects are negligible, it's just the 'forced' thing I can't see happening unless it's offered as an alternative to a custodial sentence or something similar. What drug are you talking about?
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Post by gawa on Jul 5, 2023 21:10:24 GMT
It does, be great if it works and the side effects are negligible, it's just the 'forced' thing I can't see happening unless it's offered as an alternative to a custodial sentence or something similar. What drug are you talking about? Alcohol
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Post by elystokie on Jul 5, 2023 21:12:43 GMT
It does, be great if it works and the side effects are negligible, it's just the 'forced' thing I can't see happening unless it's offered as an alternative to a custodial sentence or something similar. What drug are you talking about? The stem cell treatment.
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Post by musik on Jul 5, 2023 21:14:57 GMT
Ahhh ... two different answers. 🤠
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Post by musik on Jul 6, 2023 5:05:29 GMT
So there won't be any misunderstandings: Stem cell therapy is not a drug. In fact it's the opposite to a drug since it can be, as many wish, a treatment for drug use and abuse.
You can't miss something you have no need for.
But again as I wrote before: We must beware when nations cross limits like that and actually consider to alter people's brains. Thin ice.
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Post by elystokie on Jul 6, 2023 6:27:45 GMT
So there won't be any misunderstandings: Stem cell therapy is not a drug. In fact it's the opposite to a drug since it can be, as many wish, a treatment for drug use and abuse. You can't miss something you have no need for. But again as I wrote before: We must beware when nations cross limits like that and actually consider to alter people's brains. Thin ice. I am aware that it's not a drug, but you asked what drug I was talking about and I couldn't be bothered with an explanation as I was pretty sure you and everyone else were already aware of that fact. "You can't miss something you have no need for" Our endocannabinoid system, the system that keeps our bodies in homeostasis, evolved over millions of years to utilise the nutrients we got from eating around 800-900 different varieties of food, most people on average apparently eat 80-90 different varieties nowadays. So we're only consuming around 10% of the variety of foods our bodies are 'designed' to operate optimally on and included in that 10% are some 'foodstuffs' that our ancestors wouldn't have had access to.
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Post by musik on Jul 6, 2023 9:16:43 GMT
So there won't be any misunderstandings: Stem cell therapy is not a drug. In fact it's the opposite to a drug since it can be, as many wish, a treatment for drug use and abuse. You can't miss something you have no need for. But again as I wrote before: We must beware when nations cross limits like that and actually consider to alter people's brains. Thin ice. I am aware that it's not a drug, but you asked what drug I was talking about and I couldn't be bothered with an explanation as I was pretty sure you and everyone else were already aware of that fact. "You can't miss something you have no need for" Our endocannabinoid system, the system that keeps our bodies in homeostasis, evolved over millions of years to utilise the nutrients we got from eating around 800-900 different varieties of food, most people on average apparently eat 80-90 different varieties nowadays. So we're only consuming around 10% of the variety of foods our bodies are 'designed' to operate optimally on and included in that 10% are some 'foodstuffs' that our ancestors wouldn't have had access to. I know you knew stem cells therapy isn't a drug, ely ... What you now are trying to explain with the food reference is that people might need stuff even though someone take away the need for that stuff; they are not just aware they need the stuff. Am I correct?
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Post by musik on Jul 6, 2023 9:34:31 GMT
Wonder what the total cost is. I don't know the costs regarding ears and hearing (yet), but when it comes to joints: Not 100% sure though, but it correspond well with prices in the US I've been told. At the swedish clinic treating joints is 7000 SEK (£540) for small blood injections to help already existing stem cells locally and 55000 SEK (£4300), I think it was, for a real stem cell therapy where they take belly fat and transform these cells to cells used in joints. The outcome of it is analyzed after 6 months. At some clinics abroad they use bone marrow for different body issues.
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Post by elystokie on Jul 6, 2023 10:23:08 GMT
I am aware that it's not a drug, but you asked what drug I was talking about and I couldn't be bothered with an explanation as I was pretty sure you and everyone else were already aware of that fact. "You can't miss something you have no need for" Our endocannabinoid system, the system that keeps our bodies in homeostasis, evolved over millions of years to utilise the nutrients we got from eating around 800-900 different varieties of food, most people on average apparently eat 80-90 different varieties nowadays. So we're only consuming around 10% of the variety of foods our bodies are 'designed' to operate optimally on and included in that 10% are some 'foodstuffs' that our ancestors wouldn't have had access to. I know you knew stem cells therapy isn't a drug, ely ... What you now are trying to explain with the food reference is that people might need stuff even though someone take away the need for that stuff; they are not just aware they need the stuff. Am I correct? If you mean take away the need for that stuff in a commercial sense then yes, you're correct. We need the stuff but without spending our days re-learning and foraging it's not really feasible for us to acquire it, even if it was as readily available as it was when we evolved into what we are.
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Post by musik on Jul 6, 2023 10:56:42 GMT
I know you knew stem cells therapy isn't a drug, ely ... What you now are trying to explain with the food reference is that people might need stuff even though someone take away the need for that stuff; they are not just aware they need the stuff. Am I correct? If you mean take away the need for that stuff in a commercial sense then yes, you're correct. We need the stuff but without spending our days re-learning and foraging it's not really feasible for us to acquire it, even if it was as readily available as it was when we evolved into what we are. Would it be desirable if the need for all kind of drugs in a population disappeared completely through the intervention in the brains of a population with stem cell therapy? And do you believe everyone is addicted to food? And is every drug user addicted to drugs? I was just thinking ... what if they happened to delete the need for food. Scary business. But I was listening to some local politicians here.
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