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Post by estrangedsonoffaye on Mar 24, 2020 22:56:21 GMT
Some tentative good news from the Washington Post (paywall), the virus as sequenced from existing cases is relatively stable (remember a mutation can be just one base of RNA) and not mutating as dramatically as feared. This means any vaccine created would likely be applicable and effective once it is made.
However, this does not confer necessarily to long term immunity. As the antibody titre (how many you have to fight the specific pathogen) for most coronaviruses drops after around a year, so what this effectively means is repeat vaccinations for it could become the norm and even then, mild infection may follow.
Interestingly, Iceland has now got the capacity to do a whole island check or near enough, every case of the virus will be sequenced and as the population is quite immobile in compared to other islands, it will allow us to almost assess the virus in a control population and indeed what strains of the virus come from where.
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Post by Deleted on Mar 24, 2020 22:57:51 GMT
Great news! Donald J Trump has just announced that we (the USA) are nearing the end of our historic battle with the invisible enemy. Yes, he really just said that. This will finish him in the end. New York state will eclipse what we have seen elsewhere, they had 26,000 cases this morning FFS. I did read that part of his wall blew over in the hurricanes - that must be what did it.
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Post by Deleted on Mar 24, 2020 22:59:05 GMT
Some tentative good news from the Washington Post (paywall), the virus as sequenced from existing cases is relatively stable (remember a mutation can be just one base of RNA) and not mutating as dramatically as feared. This means any vaccine created would likely be applicable and effective once it is made. However, this does not confer necessarily to long term immunity. As the antibody titre (how many you have to fight the specific pathogen) for most coronaviruses drops after around a year, so what this effectively means is repeat vaccinations for it could become the norm and even then, mild infection may follow. Interestingly, Iceland has now got the capacity to do a whole island check or near enough, every case of the virus will be sequenced and as the population is quite immobile in compared to other islands, it will allow us to almost assess the virus in a control population and indeed what strains of the virus come from where. What do you do for a living mate?
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Post by RedandWhite90 on Mar 24, 2020 22:59:41 GMT
If ever there was a time to 'try' and find some silver linings just be thankful that this person is not directly responsible for running our country.
My liberal heart is already at breaking point for the UK, Italy (in particular MilanStokie) and the rest of Europe, but I am dreading what sort of numbers come out of America in the coming weeks.
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Post by followyoudown on Mar 24, 2020 23:06:05 GMT
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Post by mrcoke on Mar 24, 2020 23:06:13 GMT
QUESTION: Can The Corona Virus be transfered from a mosquito to a human? Just saw the first mosquito of the year in my living room just now. (Had a window opened wide, since I'm painting my kitchen.) Hope not been building my outside bar today and got bit by one of them buggers. We had a red butterfly in the garden today.
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Post by estrangedsonoffaye on Mar 24, 2020 23:07:02 GMT
Some tentative good news from the Washington Post (paywall), the virus as sequenced from existing cases is relatively stable (remember a mutation can be just one base of RNA) and not mutating as dramatically as feared. This means any vaccine created would likely be applicable and effective once it is made. However, this does not confer necessarily to long term immunity. As the antibody titre (how many you have to fight the specific pathogen) for most coronaviruses drops after around a year, so what this effectively means is repeat vaccinations for it could become the norm and even then, mild infection may follow. Interestingly, Iceland has now got the capacity to do a whole island check or near enough, every case of the virus will be sequenced and as the population is quite immobile in compared to other islands, it will allow us to almost assess the virus in a control population and indeed what strains of the virus come from where. What do you do for a living mate? I’m a pre-clinical (lab based) Neurophysiologist by trade at the Uni of Nottingham. So whilst none of this is my field of expertise, I can do my best to try and trim any jargon our of useful stories.
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Post by Deleted on Mar 24, 2020 23:09:40 GMT
Now do one for Matt Hancock......
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Post by Deleted on Mar 24, 2020 23:10:28 GMT
"...but keep going to work if you cant work from home....." Cue millions of people going to work who need to pay bills and support their family.
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Post by estrangedsonoffaye on Mar 24, 2020 23:10:32 GMT
Also, if anyone happens upon the Daily Mail headline about their being 40 strains of Coronavirus identified, please don’t read much into it. In viral terms that’s absolutely fuck all, HIV has a mutation rate of a round 0.34 mutations per replication cycle in just one person, hence why a vaccine is so difficult to make for it.
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Post by spitthedog on Mar 24, 2020 23:14:40 GMT
I think Cummings is using London for his herd immunity experiment. I wouldn't put anything past that scurrilous bastard. OS. I agree with the scurrilous bastard bit but I think RichieBarkerOut's posted link above makes it quite clear that the decision to reduce the tube service to a 'Saturday' service was totally Khan's idea and had nothing to do with drivers going off sick. So if that's what he's saying now then he clearly is lying. Probably to cover his arse rather than with the intention of blaming the Government. This is just a total distortion and blatant propaganda for people looking for a stick to beat Khan. A) The train drivers were speaking out about this very vocally 10 days ago. B) In a situation where people are meant to be staying at home, if that is indeed the Government policy, the we should not need any more than 50% of this Service running. the more trains the more staff at risk
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Post by Paul Spencer on Mar 24, 2020 23:17:40 GMT
If ever there was a time to 'try' and find some silver linings just be thankful that this person is not directly responsible for running our country. My liberal heart is already at breaking point for the UK, Italy (in particular MilanStokie) and the rest of Europe, but I am dreading what sort of numbers come out of America in the coming weeks. Just how the fuck did this moron end up being the leader of the free world? He has less maturity than that of a 10 year old.
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Post by spitthedog on Mar 24, 2020 23:21:51 GMT
If we are going to be selective The above Propaganda failed to include the following. Johnson "you could take it on the chin, take it all in one go and allow the disease, as it were, to move through the population, without taking as many draconian measures."
Spoken on National TV. This will be his legacy once the Honeymoon period is over.
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Post by Deleted on Mar 24, 2020 23:23:02 GMT
What do you do for a living mate? I’m a pre-clinical (lab based) Neurophysiologist by trade at the Uni of Nottingham. So whilst none of this is my field of expertise, I can do my best to try and trim any jargon our of useful stories. Fascinating. Your best guess - how long until we have a vaccine? Ready for the masses? 12 months? 18?
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Post by Paul Spencer on Mar 24, 2020 23:27:33 GMT
Matt Hancock in the HOC replying to who should and shouldn't go to work this afternoon ... "I want to be clear where people absolutely cannot work from home, they can still go to work, indeed it's important that they do, to keep the country running."
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Post by terryconroysmagic on Mar 24, 2020 23:28:16 GMT
What do you do for a living mate? I’m a pre-clinical (lab based) Neurophysiologist by trade at the Uni of Nottingham. So whilst none of this is my field of expertise, I can do my best to try and trim any jargon our of useful stories. So could you trim the jargon and tell us what you actually do...🤣
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Post by sheikhmomo on Mar 24, 2020 23:28:44 GMT
But go to work if you can't work from home. Tim has missed that bit of the advice off. He sounds confused.
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Post by Deleted on Mar 24, 2020 23:32:56 GMT
"Only go to work if absolutely necessary"
Keeping a roof over your head and food on the table is absolutely necessary for families up and down the country.
The Government needs to step up.
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Post by estrangedsonoffaye on Mar 24, 2020 23:34:07 GMT
I’m a pre-clinical (lab based) Neurophysiologist by trade at the Uni of Nottingham. So whilst none of this is my field of expertise, I can do my best to try and trim any jargon our of useful stories. Fascinating. Your best guess - how long until we have a vaccine? Ready for the masses? 12 months? 18? Normally these things take decades, you’d have to demonstrate efficacy in vitro (cultured cells), then in animal models and then have to go through a whole host of clinical trials before you’d even begin to get to market. The core science of something can take just a couple of years of even less its the process of getting it into trials and making sure its safe in humans that’s the time sink. We are in a good position though as vaccine efforts are already underway for MERS and SARS which can provide much of the background science needed for this sort of thing. Also, China may well have a lot to bear responsibility for, but the cognisant work by their scientists to share the sequence as early as possible when it could he isolated has sped things up dramatically. It told scientists what to aim at and where the best candidates may be. There are mechanisms in place to skip most of the red tape though and move directly into human trials, as this is an extremely pressing issue I can see this being the case so I would hazard a guess, assuming they have worthwhile candidates at around 18 months, assuming the virus is as stable as they reckon it to be.
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Post by BristolMick on Mar 24, 2020 23:37:21 GMT
I've seen quite a few in my long lifetime, but Trump is the most crazy human I've ever seen. He really does belong on another planet. Why on earth don't they just arrest him and send him to Nurse Ratched? The lunatic will kill millions if they allow him to stay in office. OS. The one and only good thing that’s going to come from this virus is that one way or another it will be the end of him. It would be fantastic if it killed him but if instead his approach to it means he gets slaughtered in the November election that would be a good second best. BM
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Post by Deleted on Mar 24, 2020 23:40:33 GMT
Fascinating. Your best guess - how long until we have a vaccine? Ready for the masses? 12 months? 18? Normally these things take decades, you’d have to demonstrate efficacy in vitro (cultured cells), then in animal models and then have to go through a whole host of clinical trials before you’d even begin to get to market. The core science of something can take just a couple of years of even less its the process of getting it into trials and making sure its safe in humans that’s the time sink. We are in a good position though as vaccine efforts are already underway for MERS and SARS which can provide much of the background science needed for this sort of thing. Also, China may well have a lot to bear responsibility for, but the cognisant work by their scientists to share the sequence as early as possible when it could he isolated has sped things up dramatically. It told scientists what to aim at and where the best candidates may be. There are mechanisms in place to skip most of the red tape though and move directly into human trials, as this is an extremely pressing issue I can see this being the case so I would hazard a guess, assuming they have worthwhile candidates at around 18 months, assuming the virus is as stable as they reckon it to be. Not sure I understood most of that but thanks for taking the time to respond and explain. End of next year is probably best case then? Jesus wept. We need to adjust to a new norm.
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Post by estrangedsonoffaye on Mar 24, 2020 23:44:16 GMT
Normally these things take decades, you’d have to demonstrate efficacy in vitro (cultured cells), then in animal models and then have to go through a whole host of clinical trials before you’d even begin to get to market. The core science of something can take just a couple of years of even less its the process of getting it into trials and making sure its safe in humans that’s the time sink. We are in a good position though as vaccine efforts are already underway for MERS and SARS which can provide much of the background science needed for this sort of thing. Also, China may well have a lot to bear responsibility for, but the cognisant work by their scientists to share the sequence as early as possible when it could he isolated has sped things up dramatically. It told scientists what to aim at and where the best candidates may be. There are mechanisms in place to skip most of the red tape though and move directly into human trials, as this is an extremely pressing issue I can see this being the case so I would hazard a guess, assuming they have worthwhile candidates at around 18 months, assuming the virus is as stable as they reckon it to be. Not sure I understood most of that but thanks for taking the time to respond and explain. End of next year is probably best case then? Jesus wept. We need to adjust to a new norm. Basically, they’re fast-tracking the process and skipping out a lot of the validation procedures you would normally expect developing a new vaccine. But the potential benefits of bringing it through quickly and it not working by far outweigh the benefits of waiting around for years. There is also the immunity provided by being infected which will more or less be a year they think, so that is why the post infection test is absolutely key, if they can show most people have had it we can start returning to normal and buy time for the vaccine. Just be reassured, we have never been in a better position to deal with a pandemic in any point in history as we are now. The stuff we can do these days is honestly amazing and miles ahead of anything we could even do a couple of years ago. We’ll get there!
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Post by Laughing Gravy on Mar 24, 2020 23:44:21 GMT
I agree with the scurrilous bastard bit but I think RichieBarkerOut's posted link above makes it quite clear that the decision to reduce the tube service to a 'Saturday' service was totally Khan's idea and had nothing to do with drivers going off sick. So if that's what he's saying now then he clearly is lying. Probably to cover his arse rather than with the intention of blaming the Government. This is just a total distortion and blatant propaganda for people looking for a stick to beat Khan. A) The train drivers were speaking out about this very vocally 10 days ago. B) In a situation where people are meant to be staying at home, if that is indeed the Government policy, the we should not need any more than 50% of this Service running. the more trains the more staff at risk I have no idea mate but are you saying that article in the link is wrong? I've not researched it, just read it.
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Post by Deleted on Mar 24, 2020 23:48:44 GMT
Not sure I understood most of that but thanks for taking the time to respond and explain. End of next year is probably best case then? Jesus wept. We need to adjust to a new norm. Basically, they’re fast-tracking the process and skipping out a lot of the validation procedures you would normally expect developing a new vaccine. But the potential benefits of bringing it through quickly and it not working by far outweigh the benefits of waiting around for years. There is also the immunity provided by being infected which will more or less be a year they think, so that is why the post infection test is absolutely key, if they can show most people have had it we can start returning to normal and buy time for the vaccine. Just be reassured, we have never been in a better position to deal with a pandemic in any point in history as we are now. The stuff we can do these days is honestly amazing and miles ahead of anything we could even do a couple of years ago. We’ll get there! Ok, next question! When will post infection tests be available? And how or who gets tested? The poeple that have had it and recovered surely wont be actively seeking any tests. How does that work? Sorry for all the questions!!
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Post by spitthedog on Mar 24, 2020 23:51:22 GMT
But go to work if you can't work from home. Tim has missed that bit of the advice off. He sounds confused. He's also missed the quote from Michael Gove this morning saying "people from the Finance Sector are essential workers and should go to work" We that's a quarter of a million people.750,000 every day...so that's why they are having a go at Khan. Really!...these huge corporates don't have the facility to work from home. How the hell is that a Stay at Home Policy??
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Post by Laughing Gravy on Mar 24, 2020 23:57:56 GMT
For anyone self employed my mate Martin Lewis (we're bessie's) has just emailed me this:-
1) SELF EMPLOYED/FREELANCE? Try to hold on - the support package should come this week. There's a real feeling of panic growing among the UK's self-employed. While there are some measures in place, they're simply not enough yet, so I've two important points...
a) I have it officially CONFIRMED the Govt is working on a further support package (some reports say it'll be as soon as Wed, but it'll almost certainly be by Fri). I don't know what it is, but suspect it'll be on a par with the 80% of your salary up to £2,500 for employees. So hold tight, and don't make any drastic decisions until that's announced. b) Check the measures already in place to see if they can help, including deferring tax payments and claiming employment support allowance if you're sick. Plus crucially, don't dismiss universal credit (see below for why).
Joking apart I hope this helps ease your worries.
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Post by spitthedog on Mar 25, 2020 0:01:17 GMT
This is just a total distortion and blatant propaganda for people looking for a stick to beat Khan. A) The train drivers were speaking out about this very vocally 10 days ago. B) In a situation where people are meant to be staying at home, if that is indeed the Government policy, the we should not need any more than 50% of this Service running. the more trains the more staff at risk I have no idea mate but are you saying that article in the link is wrong? I've not researched it, just read it. The article isnt wrong. The point is the article justifies Khan's position. Mr Khan replied: "What we are going to do is make sure there is a good public transport service available for those who need it." i.e. 50% of the normal service. Train Drivers Unions had been telling Khan they cant guarantee a full work force more than a week ago. Those who need it should not exceed 50% of the usual service. To get a grip of this virus we need less than 50% of usual commuters to be using the service NOT more as advocated by Hancock. The problem is Gove coming out and saying 750,000 Financial sector workers should go to work as normal in London. That is not a Stay at Home Policy. That is a deadly Go To Work Policy. That is the equivalent of sending people to Gas chambers. These mixed messages will Kill many of our population, it sounds dramatic but this is the truth, based on all of the evidence we have about this Virus.
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Post by estrangedsonoffaye on Mar 25, 2020 0:06:57 GMT
Basically, they’re fast-tracking the process and skipping out a lot of the validation procedures you would normally expect developing a new vaccine. But the potential benefits of bringing it through quickly and it not working by far outweigh the benefits of waiting around for years. There is also the immunity provided by being infected which will more or less be a year they think, so that is why the post infection test is absolutely key, if they can show most people have had it we can start returning to normal and buy time for the vaccine. Just be reassured, we have never been in a better position to deal with a pandemic in any point in history as we are now. The stuff we can do these days is honestly amazing and miles ahead of anything we could even do a couple of years ago. We’ll get there! Ok, next question! When will post infection tests be available? And how or who gets tested? The poeple that have had it and recovered surely wont be actively seeking any tests. How does that work? Sorry for all the questions!! No problem mate, happy to help anyway I can. So the current test we have uses something called PCR, which essentially amplifies up the genetic material in a sample and you can target the viral dna/rna within the sample. Imagine you have a pint and split it in two, and then have a supply of beer to top the halves up with, you now have two pints. Do the same again, you have 4 and you do this 36 times you’d have a lot of pints. That’s essentially what we do to DNA to then measure, the DNA sample is the first pint which we split in half (DNA is has two strands) and the top up beer is a genetic mix we have to make the double strand again, or a full pint. 😂 The trouble is, this only works if the virus is actually in cells, and that is only when sample are taken from actively infectious people so it’s only a snapshot in time. The post infection test, will be able to detect antibodies to the virus floating around in your blood, so a simply blood sample should suffice and then you can purify it for the antibodies you’re looking for and see how strongly they bond to a viral protein on a plate. A strong bind equals a lot of antibodies and likely immunity, weak to no binding indicates you were never exposed to the virus at all. The key thing is validating the kits, which we are told is a couple of weeks away, then rolling them out. I imagine we may have a compulsory blood test to take, or it may be a condition of returning to work that you have one. But I couldn’t tell you more as I still think Public Health England are ironing all this out.
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Post by Gods on Mar 25, 2020 0:09:09 GMT
Men are x2 more likely to die from COVID-19 than women.
Dr. Deborah Birx, the White House's coronavirus response coordinator, said at a White House press briefing: "From Italy we're seeing another concerning trend. That the mortality in males seems to be twice in every age group of females."
Smoking, drinking and general poor health of many males is being blamed for this.
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Post by Deleted on Mar 25, 2020 0:09:10 GMT
But go to work if you can't work from home. Tim has missed that bit of the advice off. He sounds confused. He's also missed the quote from Michael Gove this morning saying "people from the Finance Sector are essential workers and should go to work" We that's a quarter of a million people.750,000 every day...so that's why they are having a go at Khan. Really!...these huge corporates don't have the facility to work from home. How the hell is that a Stay at Home Policy?? I have to agree. I must admit that I was pretty angry after that last charade by Boris. There was a build up. The timing was changed to "peak time". Tussle haired Boris sat there trying to look serious and glum. He spoke.
I then sat and thought for at least 30 seconds, and decided "so nothing has significantly changed that will make a difference then" We already knew about the 2m rule, and hand washing.
Someone on here suggested that if the retail sector in London has been closed down, then a skeleton transport staff should suffice. Lock down the finance AND the retail sector and you may be nearer to the mark. That will be sometime coming ....... You would have thought though that locking down the finance sector would be easier than closing all of the shops? After all, we no longer have telegrams and letters and stuff used in the financial sector, it is all digital?
People are suggesting that London as a city should get locked down (I mean really locked down, not this quasi lock down) - I'm no expert but that might work? Sounds brutal I know. New York is looking horrendous at the moment ....
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